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July 18, 2014
Upcoming Seminar: by Jean Rosenbaum
May 20, 2014
Event: Kumadai-Todai joint CREST meeting
May 12, 2014
Seminar: by Professor Jean Pieters
April 18, 2014
Seminar: by Professor Hiromi Kubagawa

Latest Publications Backnumber

Maehara N, Taniguchi K, Okuno A, Ando H, Hirota A, Li Z, Wang C-T, Arai S, & Miyazaki T. AIM/CD5L attenuates DAMPs in the injured brain and thereby ameliorates ischemic stroke. Cell Rep. 36, 109693 (2021).

Lee J Y, Arumugarajah S, Lian D, Maehara N, Haig A R, Suri R S, Miyazaki T, & Gunaratna L. Recombinant Apoptosis Inhibitor of Macrophage Protein Reduces Delayed Graft Function in a Murine Model of Kidney Transplantation. PloS One. 16, e0249838 (2021).

Hasegawa H, Mizoguchi I, Orii N, Inoue S, Katahira Y, Yoneto T, Xu M, Miyazaki T & Yoshimoto T. IL-23p19 and CD5 antigen-like form a possible novel heterodimeric cytokine and contribute to experimental autoimmune encephalomyelitis development. Sci. Rep. 11, 5266 (2021).

Takahata A, Arai S, Hiramoto E, Kitada K, Makita Y, Suzuki H, Nakata J, Araki K, Miyazaki T & Suzuki Y. Crucial role of AIM/CD5L in the development of glomerular inflammation in IgA Nephropathy. J. Am. Soc. Nephrol. 31, 2013-2024. (2020).

Komatu G, Nonomura T, Sasaki M, Ishida S, & Miyazaki T.
AIM-deficient mouse fed a high-trans fat, high-cholesterol diet: a new animal model for nonalcoholic fatty liver disease. Exp Anim. 68(2): 147–158 (2019).

Sugisawa R, Komatsu G, Hiramoto E, Takeda N, Yamamura K-I, Arai S, & Miyazaki T.
Independent modes of disease repair by AIM protein distinguished in AIM-felinized mice. Sci Rep. 8, 13157 (2018).

Hiramoto E, Tsutsumi A, Suzuki R, Matsuoka S, Arai S, Kikkawa M, & Miyazaki T.
The IgM pentamer is an asymmetric pentagon with an open groove that binds the AIM protein. Sci Adv. 4: eaau1199 (2018).

Koyama N, Yamazaki T, Kanetsuki Y, Hirota J, Asai T, Mitsumoto Y, Mizuno M, Shima T, Kanbara Y, Arai S, Miyazaki T, & Okanoue T.
Activation of apoptosis inhibitor of macrophage is a sensitive diagnostic marker for NASH-associated hepatocellular carcinoma. J Gastroenterol. 53:770-779 (2018).

Tomita T, Arai S, Kitada K, Mizuno M, Suzuki Y, Sakata F, Nakano D, Hiramoto E, Takei Y, Maruyama S, Nishiyama A, Matsuo S, Miyazaki T, & Ito Y
Apoptosis inhibitor of macrophage ameliorates fungus-induced peritoneal injury model in mice.
Sci Rep. 7, 6450 (2017).

Matsumoto, A., Taniguchi, K., Takeda, N., Yamamura-KI., Arai, S. & Miyazaki, T.
Inflammatory and anti-inflammatory states of adipose tissue in transgenic mice bearing a single TCR.
Int. Immunol. 29: 21-30 (2017).

Miyazaki, T. & Arai, S.
AIM associated with the IgM pentamer: attackers standing by on an aircraft carrier.
Curr. Top. Microbio. Immunol. (in press, 2017).

Yamazaki, T., Sugisawa, R., Hiramoto, E., Takai, R., Matsumoto, A., Senda, Y., Nakashima, K., Nelson, P. S., Lucas, J. M., Morgan, A., Li, Z., Yamamura, KI., Arai, S., Miyazaki, T. 
A proteolytic modification of AIM promotes its renal excretion
Sci Rep. 6, 38762 (2016).

Ozawa, T., Maehara, N., Kai T., Arai, S., Miyazaki, T.
Dietary fructose-induced hepatocellular carcinoma development manifested in mice lacking apoptosis inhibitor of macrophage (AIM)
Genes Cells. 21, 1320-1332 (2016).

Sugisawa, R., Hiramoto, E., Matsuoka, S., Iwai, S., Takai, R., Yamazaki, T., Mori, N., Okada, Y., Takeda, N., Yamamura, KI., Arai, T., Arai, S., & Miyazaki, T.
Impact of feline AIM on the susceptibility of cats to renal disease
Sci Rep. 6, 35251 (2016).

Arai, S., Kitada, K., Yamazaki, T., Takai, R., Zhang, X., Tsugawa, Y., Sugisawa, R., Matsumoto, A., Mori, M., Yoshihara, Y., Doi, K., Maehara, N., Kusunoki, S., Takahata, A., Noiri, E., Suzuki, Y., Yahagi, N., Nishiyama, A., Gunaratnam, L., Takano, T. & Miyazaki, T.
Apoptosis inhibitor of macrophage protein enhances intraluminal debris clearance and ameliorates acute kidney injury in mice
Nat Med. 22, 183-93 (2016).

Yamazaki, T., Mori, M., Arai, S., Tateishi, R., Abe, M., Ban, M., Nishijima, A., Maeda, M., Asano, T., Kai, T., Izumino, K., Takahashi, J., Aoyama, K., Harada, S., Takebayashi, T., Gunji, T., Ohnishi, S., Seto, S., Yoshida, Y., Hiasa, Y., Koike, K., Yamamura, K., Inoue, K. & Miyazaki, T.
Circulating AIM as an Indicator of Liver Damage and Hepatocellular Carcinoma in Humans
PLoS One. 9, e109123 (2014).

Maehara, N., Arai, S., Mori, M., Iwamura, Y., Kurokawa, J., Kai, T., Kusunoki, S., Taniguchi, K., Ikeda, K., Ohara, O., Yamamura, K. & Miyazaki, T.
Circulating AIM Prevents Hepatocellular Carcinoma through Complement Activation
Cell Rep. 9, 61-74 (2014).

Kai, T., Yamazaki, T., Arai, S. & Miyazaki, T.
Stabilization and Augmentation of Circulating AIM in Mice by Synthesized IgM-Fc
PLoS One. 9, e97037 (2014).

Arai, S. & Miyazaki, T.
Impacts of the apoptosis inhibitor of macrophage (AIM) on obesity-associated inflammatory diseases 
Semin Immunopathol. 36, 3-12 (2014).